The dose should not exceed mg daily. For extended release tablets, the usual dose is 30 or 60 mg once daily. The maximum dose is mg daily. Hypertension is treated with mg daily using extended release tablets. Nifedipine can be taken with or without food.

The tablets and capsules should be swallowed whole and not bitten or cut in half. Exercise Tips Which drugs or supplements interact with nifedipine? Some of the symptoms of an allergic reaction may include: Do not take Adalat Oros if you are in cardiogenic shock very low blood pressure due to a failing heart. Tell your doctor if you have had a heart attack in the last week or so.

Do not take Adalat Oros if you have a Kock Pouch or ileostomy a surgically created reservoir in the small intestine. Do not take Adalat Oros if you are taking another medicine containing the active substance rifampicin, an antibiotic used to treat tuberculosis and other serious infections.

Do not take this medicine if you are pregnant. It may affect your developing baby if you take it during pregnancy. Do not breast-feed if you are taking this medicine. The active ingredient in Adalat Oros passes into breast milk and there is a possibility that your baby may be affected.

Do not take this medicine after the expiry date printed on the pack and blister. The expiry date refers to the last day of that month. If it has expired return it to your pharmacist for disposal.

Do not take this medicine if the packaging is torn or shows signs of tampering. If the packaging is damaged, return it to your pharmacist for disposal. Do not take tablets that show visible signs of deterioration e. If you are not sure whether you should start taking this medicine, talk to your doctor. Before you start to take it Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. Tell your doctor if you have or have had any of the following medical conditions: Tell your doctor if you eat grapefruit or drink grapefruit juice regularly, including in the last 3 days before starting Adalat Oros.

You should not have grapefruit while you are taking Adalat Oros because this can cause unwanted changes in the blood pressure lowering effect of the tablets. Taking other medicines Tell your doctor or pharmacist if you are taking any other medicines, including those that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines and Adalat Oros may interfere with each other. How to take it The tablets must not be chewed or broken up. They are to be swallowed whole with some liquid.

They can be taken either with or without a meal. Do not halve the tablets. When to take it The tablets should generally be taken in the morning. Otherwise, skip that day's dose but be sure to take the next day's dose when it is due. Do NOT take a double dose to make up for the dose you missed. If you have missed several doses, consult your doctor. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Signs of an overdose include feeling dizzy and fainting due to drop in blood pressure, irregular or rapid heart beats, shortness of breath and even loss of consciousness.

If you do not follow your doctor's instruction, you may not get control of your blood pressure or relief from your angina. Things you must not do Do not give this medicine to anyone else, even if their symptoms seem similar to yours. ADALAT OROS may cause dizziness or fainting in some patients who have low blood pressure, especially when they first start taking the medicine, change dose, or drink alcohol.

You may feel better when you start taking it, but you will need time to improve your physical fitness. Sometimes they are serious, most of the time they are not. Special warnings and precautions for use Be used with caution in patients with very low blood pressure severe hypotension with systolic blood pressure lower than 90 mm Hg , in cases of overt heart failure and in cases of severe aortic stenosis. As with other non-fissile materials see instructions for use Adalat OROS 30 should be used with caution in patients with pre-existing severe gastrointestinal narrowing, due to possible occurrence of obstructive symptoms.

In very rare cases can form stones and surgicsl interventsiya. V single cases described symptoms of obstructive symptoms with no history of gastrointestinal narusheniya. Vnimatelno not be used in pregnant women when used in combination with nifedipine magnesium sulfate iv see Contraindications. In patients with impaired liver function should be carefully monitored and in severe cases it may be necessary to reduce the dose.

Effects on ability to drive and use machines Reactions to the drug, which vary in intensity in different individuals may impair ability to drive or operate machinery. This applies especially to the beginning of the treatment, on changing the medication and in combination with alcohol. Drug Interactions Interactions with other drugs The effect of lowering the blood pressure of nifedipine can be enhanced by other antihypertensives lekarstva.

Kogato nifedipine is administered simultaneously with the beta-blockers. It is also known worsening heart failure in some cases. Nifedipine is metabolized by cytochrome P ZA4. Drugs which are known to inhibit or induce this enzyme system may therefore alter the first pass after oral administration or the clearance of nifedipine.

Therefore, as a precaution, the patient should be examined for symptoms of digoxin overdose and, if necessary glycoside dose should be reduced by taking the plasma kontsentratsiya. When co-administered with phenytoin, the bioavailability of nifedipine is reduced and thus its efficacy weakened. When two drugs are administered at the same time must be monitored clinical response to nifedipine and if necessary to increase the dose of nifedipine. If the dose of nifedipine is increased during co-administration of both drugs, the dose of nifedipine should be reduced when phenytoin is prekasva.

Kogato nifedipine and quinidine are administered simultaneously, the concentration of quinidine is reduced or after discontinuation of nifedipine, in some cases there was a significant increase in the plasma concentration of quinidine.

For this reason, when nifedipine is included additionally or withdrawn it is recommended to monitor the plasma concentration of quinidine, and if necessary, adjust the dosage of quinidine. Some authors reported increased plasma concentrations of nifedipine during concomitant administration of both drugs, while others did not observe changes in the pharmacokinetics of nifedipine.

Therefore, blood pressure should be carefully monitored if quinidine is added to an existing therapy with nifedipine. If necessary, the dose of nifedipine should be decreased. Simultaneous administration of both drugs, blood pressure should be monitored and, if necessary to reduce the dose of nifedipine. Pimetidin Due to its inhibition of cytochrome P ZA4, cimetidine increases the plasma concentrations of nifedipine and may potentiate the antihypertensive effect.

Nifedipine

Erythromycin, adalat oros 30mg, a CYP3A inhibitor, can inhibit the metabolism of nifedipine and increase the exposure to nifedipine during concomitant therapy. Up to 20 to 30 mg every oros daily may be required. In view adalat the high variability of nifedipine pharmacokinetics, the clinical significance of this oro is unknown. Caution adalat be exercised when co-administering diltiazem and nifedipine and a oro of the dose of nifedipine should be considered. Nifedipine tends to oro hyperglycemia and may lead to loss of glucose control. Opitat calcium antagonist nimodipine shows that the possibility of 30mg of carbamazepine or phenobarbital medicines 30mg to treat epilepsy attenuated the effect of nifedipine. A hypotensive effect was only seen after co-administration of the two drugs. It adalat by relaxing blood vessels so blood can flow adalat easily, adalat oros 30mg. This is thought to be a function of inhibition of calcium 30mg across the platelet membrane. Nifedipine has been shown to inhibit the metabolism of 30mg in vitro.

Medicamentos Antihipertensivos, efectos secundarios frecuentes

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