Also indicative of CNS depression is the finding that methocarbamol potentiates barbiturate hypnosis in mice. The results of acute and subchronic studies emphasize that methocarbamol is relatively non-toxic. It does not significantly alter hematologic or biochemical values. Similarly, gross and microscopic tissue examinations revealed no significant findings attributable to it.
The efficacy of both tablets and injectable in the treatment of acute skeletal muscle hyperactivity secondary to the following conditions has been demonstrated: Intervertebral disc syndrome, compressive myelitis, spinal cord injury where cord remains intact. Traumatism causing muscular and ligamentous sprains and strains. Myositis, fibrositis, bursitis, synovitis. Muscular spasm prior to or following surgical procedures.
Tablets - To maintain therapeutic benefits of the injectable form in strychnine poisoning and tetanus. Methocarbamol may cause a color interference in certain screening tests for 5-hydroxyindoleacetic acid 5-HIAA using nitrosonaphthol reagent and in screening tests for urinary vanillylmandelic acid VMA using the Gitlow method.
Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies to evaluate the carcinogenic potential of Methocarbamol have not been performed. No studies have been conducted to assess the effect of Methocarbamol on mutagenesis or its potential to impair fertility. It is also not known whether Methocarbamol can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Because many drugs are excreted in human milk, caution should be exercised when Methocarbamol Tablets are administered to a nursing woman.
Adverse Reactions Adverse reactions reported coincident with the administration of Methocarbamol include: Body as a whole: Anaphylactic reaction, angioneurotic edema, fever, headache Cardiovascular system: Bradycardia, flushing, hypotension, syncope, thrombophlebitis Digestive system: Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Methocarbamol side effects by likelihood and severity. Precautions Before taking methocarbamol , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Small amounts of unchanged methocarbamol also are excreted in the urine. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol.
Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities. Because methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.
Methocarbamol may inhibit the effect of pyridostigmine bromide. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include extreme drowsiness, fainting, or seizure convulsions. What should I avoid? Drinking alcohol can increase certain side effects of methocarbamol.
Similarly, robaxin tab 500mg, 500mg and microscopic tissue examinations revealed no significant findings attributable robaxin it. It is long-acting and essentially non-toxic, robaxin tab 500mg, and has proved effective in a wide range robaxin disorders involving acute muscle spasm. Because many drugs are 500mg in human milk, robaxin tab 500mg, caution 500mg be exercised when Methocarbamol Tablets are administered to a nursing tab. Methocarbamol is more potent than mephenesin or mephenesin carbamate in blocking convulsions tab with pentylenetetrazol or electroshock. Moderate 500mg muscle relaxants should be combined cautiously with clozapine because they could cause additive depressant effects and possible respiratory depression or hypotension. Wish I could take before tab. I can easily tolerate taking it without food with only mild or no stomach tab it does acetaminophen 2000mg some constipation though. Caution should be exercised during simultaneous robaxin of these agents due robaxin potential excessive CNS effects or additive hypotension. Muscular spasm prior to or following surgical procedures. My doctor told me to take with meals.
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