Side Effects Drowsiness, dizziness , lightheadedness , blurred vision , constipation , or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth , suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS.

Get medical help right away if you have any of the following symptoms: A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects.

If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Compazine side effects by likelihood and severity. Precautions Before taking prochlorperazine , tell your doctor or pharmacist if you are allergic to it; or to other phenothiazines such as chlorpromazine ; or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication , tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products. This medication may make you more sensitive to the sun. Anticholinergic Agents may enhance the anticholinergic effect of OnabotulinumtoxinA. Monitor therapy Opioid Analgesics: Avoid concomitant use of opioid analgesics and benzodiazepines or other CNS depressants when possible.

Consider therapy modification Orphenadrine: Avoid concomitant use of oxycodone and benzodiazepines or other CNS depressants when possible. Consider therapy modification Paraldehyde: Patients taking perampanel with any other drug that has CNS depressant activities should avoid complex and high-risk activities, particularly those such as driving that require alertness and coordination, until they have experience using the combination. Consider therapy modification Piribedil: Antipsychotic Agents may diminish the therapeutic effect of Piribedil.

Piribedil may diminish the therapeutic effect of Antipsychotic Agents. Use of piribedil with antiemetic neuroleptics is contraindicated, and use with antipsychotic neuroleptics, except for clozapine, is not recommended. Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Monitor therapy Potassium Chloride: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Chloride.

Patients on drugs with substantial anticholinergic effects should avoid using any solid oral dosage form of potassium chloride. Avoid combination Potassium Citrate: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Citrate. These effects are specific to the GI tract. Consider therapy modification Quinagolide: Antipsychotic Agents may diminish the therapeutic effect of Quinagolide.

Anticholinergic Agents may enhance the constipating effect of Ramosetron. Anticholinergic Agents may enhance the anticholinergic effect of RimabotulinumtoxinB. Specifically, sleepiness and dizziness may be enhanced. Antipsychotic Agents Phenothiazines may enhance the arrhythmogenic effect of Saquinavir.

Anticholinergic Agents may diminish the therapeutic effect of Secretin. Avoid concomitant use of anticholinergic agents and secretin. Discontinue anticholinergic agents at least 5 half-lives prior to administration of secretin. Consider therapy modification Selective Serotonin Reuptake Inhibitors: Specifically, the risk of psychomotor impairment may be enhanced.

Monitor therapy Serotonin Modulators: Specifically, serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotic Agents may enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. Specifically, this may be manifest as symptoms consistent with serotonin syndrome or neuroleptic malignant syndrome. Monitor therapy Sodium Oxybate: Consider alternatives to combined use.

When combined use is needed, consider minimizing doses of one or more drugs. Use of sodium oxybate with alcohol or sedative hypnotics is contraindicated.

Consider therapy modification Sulpiride: Use of suvorexant with alcohol is not recommended, and the use of suvorexant with any other drug to treat insomnia is not recommended. Consider therapy modification Tapentadol: Avoid concomitant use of tapentadol and benzodiazepines or other CNS depressants when possible. Consider therapy modification Tetrabenazine: Avoid combination Thiazide and Thiazide-Like Diuretics: Anticholinergic Agents may enhance the anticholinergic effect of Tiotropium.

Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Reduce the Intermezzo brand sublingual zolpidem adult dose to 1.

No such dose change is recommended for women. Avoid use with other CNS depressants at bedtime; avoid use with alcohol. Consider therapy modification Test Interactions False-positives for phenylketonuria, pregnancy Adverse Reactions Frequency not defined. Reactions listed are based on reports for other agents in this same pharmacologic class and may not be specifically reported for prochlorperazine. ECG abnormality Q wave and T wave distortions , hypotension, peripheral edema Central nervous system: Agitation, altered cerebrospinal proteins, catatonia, cerebral edema, coma, decreased cough reflex, disruption of body temperature regulation, dizziness, drowsiness, dystonia carpopedal spasm, protrusion of tongue, torticollis, trismus , extrapyramidal reaction akathisia, dystonias, hyperreflexia, pseudoparkinsonism, tardive dyskinesia , headache, hyperpyrexia, insomnia, neuroleptic malignant syndrome NMS , opisthotonos, restlessness, seizure Dermatologic: Amenorrhea, change in libido, galactorrhea, gynecomastia, glycosuria, hyperglycemia, hypoglycemia, menstrual disease, weight gain Gastrointestinal: Atony of colon, cholestasis, increased appetite, constipation, intestinal obstruction, nausea, obstipation, vomiting, xerostomia Genitourinary: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, immune thrombocytopenia, leukopenia, pancytopenia Hepatic: Lupus-like syndrome, tremor Ophthalmic: Blurred vision, cataract, epithelial keratopathy, corneal deposits, miosis, mydriasis, oculogyric crisis, retinitis pigmentosa Respiratory: Asphyxia, asthma, laryngeal edema, nasal congestion Miscellaneous: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Analyses of 17 placebo-controlled trials modal duration of 10 weeks , largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients between 1. Over the course of a typical week controlled trial, the rate of death in drug-treated patients was approximately 4. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular eg, heart failure, sudden death or infectious eg, pneumonia in nature.

Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality.

The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic s of the patients is not clear. Prochlorperazine is not approved for the treatment of patients with dementia-related psychosis.

May alter cardiac conduction life-threatening arrhythmias have occurred with therapeutic doses of phenothiazines. May cause anticholinergic effects constipation, xerostomia, blurred vision, urinary retention ; use with caution in patients with decreased gastrointestinal motility, paralytic ileus, urinary retention, BPH, xerostomia, or visual problems.

Aspiration of vomit has occurred in postsurgical patients who have received prochlorperazine as an antiemetic case reports. Although no causal relationship has been established, this possibility should be considered during post-surgical care.

Caution and dose reduction are recommended in patients with severe hepatic impairment. Chlorpromazine is a phenothiazine with broad-spectrum D2, histamine [H1], alphaadrenergic, and cholinergic [M1—5] receptor antagonist properties. Dose-limiting sedation is a problem but may be useful in a distressed, dying patient. Other side effects, including confusion, respiratory depression, EPSs, and anticholinergic effects, are common.

Similar to all phenothiazines, it may affect the QTc interval and the white count and may lower seizure thresholds. It causes fewer EPSs than other antipsychotics92,93; the main side effects are somnolence and weight gain. Dry mouth, constipation, increased appetite, agitation, hyperglycemia, and edema have also been reported. Dosing is not established in children, although it has been used in adolescents.

Prochlorperazine

Aspirin, Acetaminophen, Caffeine pills One time dose of 2 pills each containing acetaminophen mg, aspirin mg and caffeine 65mg in each tablet. Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid Topical. QT prolongation is exacerbated, in particular, in the presence of bradycardia, hypokalaemia, and congenital or acquired i. Since 10mg treated with antipsychotics often present with acquired risk factors for VTE, compazine 10mg iv, all possible risk factors for VTE should be identified before and during treatment with Prochlorperazine and preventive measures undertaken. I always push over 2 mins and flush afterwards if they don't have IVF but most already do. Asphyxia, compazine 10mg iv, asthma, laryngeal edema, nasal congestion Miscellaneous: Early in therapy watch for pseudoparkinson's and acute dyskinesia. Therefore, this medication is not recommended compazine use in children who are in surgery or have a short-term illness e. Howmany tablets should you administer? Specifically, the risk of psychomotor impairment may be enhanced. Consider therapy modification Ipratropium Oral Inhalation: Anticholinergic Agents may enhance the anticholinergic effect of Cimetropium.

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If you are taking prochlorperazine on a regular schedule several times a day, take the missed dose within 1 hour of its regular time. Precautions Before taking prochlorperazinetell your doctor or pharmacist if you are allergic to it; or to other phenothiazines such as chlorpromazine ; or if you 40mg adderall tablet any other allergies. Major Oral compounds compazine to interact with antacids, like phenothiazines, should not be taken within 2 hours of dosing with lanthanum carbonate. The use of Prochlorperazine injection is contraindicated in children as it has been associated with dystonic reactions after the cumulative dose of 0. Because antipsychotics can cause or exacerbate 10mg and SIADH and the elderly are at increased risk of developing these conditions, sodium levels should be closely monitored when starting or changing dosages of antipsychotics in older adults, compazine 10mg iv. As with all antipsychotic drugs, Prochlorperazine Injection should not be used alone where depression is predominant. Benadryl should be given PRN not as an adjunct. After the first fingolimod dose, overnight monitoring with continuous ECG in a medical facility is advised for patients taking QT 10mg drugs with a known risk of torsades de pointes TdP. Moderate Androgen deprivation therapy e. Aspirin, Acetaminophen, Caffeine pills One time 10mg of 2 pills each compazine acetaminophen mg, aspirin mg and caffeine 65mg in each tablet. Minor Due to a possible risk for QT prolongation and compazine de pointes TdPazithromycin and prochlorperazine should be used together cautiously. Drugs with a possible risk for 10mg prolongation and TdP that should be used cautiously and with close monitoring with ketoconazole include prochlorperazine. Consequently, newborns should be monitored carefully, compazine 10mg iv. Red, dry, hot skin; full bounding pulse; dilated pupils; dyspnea; confusion; temperature over Prochlorperazine is associated with a possible risk for QT prolongation, particularly in overdose settings. According to the manufacturer of citalopram, ECG monitoring is recommended in compazine receiving concurrent drugs that prolong the QT interval. These effects may be potentiated during concurrent use of loxapine and other antipsychotics, compazine 10mg iv.

Neuroleptic Poisoning Damage

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