This "umbrella" of the benzodiazepines is the main reason for the success of diazepam tapering. The high accumulation levels produced by the diazepam active metabolites also reduces the probability of tolerance problems during tapering. There values are not necessarily the same as therapeutically effective doses, but sometimes are. Mild daytime sedation at the end of a weeks exchange suggests the equivalent dose is correct. Each person should find the rate suitable to themselves.
Clonazepam is one of the nitro-benzodiazepines series, i. It has a half-life of hours and accumulates from 1. Most of it is eliminated from the body in 5—10 days.
Different authorities show different equivalencies and your doctor has chosen one on the low end of the scale. Good luck whatever you do. But as you said, I'll tapper it off gradually, not just stop it at once. Sorry for the misunderstanding.
I'm not quite sure from your last message what your plan is. No need for a cross-over now, it's been 9 days. I would ask your doctor to look again at the equivalency tables and see if he should updose you a bit to like 15mgs or so. There may also be non-teratogenic risks associated with the use of benzodiazepines during pregnancy.
There have been reports of neonatal flaccidity, respiratory and feeding difficulties and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy.
In addition, children born to mothers receiving benzodiazepines late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period. Advice Regarding the Use of Clonazepam in Women of Childbearing Potential In general, the use of clonazepam in women of childbearing potential, and more specifically during known pregnancy, should be considered only when the clinical situation warrants the risk to the fetus.
The specific considerations addressed above regarding the use of anticonvulsants for epilepsy in women of childbearing potential should be weighed in treating or counseling these women. Because of experience with other members of the benzodiazepine class, clonazepam is assumed to be capable of causing an increased risk of congenital abnormalities when administered to a pregnant woman during the first trimester. Because use of these drugs is rarely a matter of urgency in the treatment of panic disorder, their use during the first trimester should almost always be avoided.
The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Patients should also be advised that if they become pregnant during therapy or intend to become pregnant, they should communicate with their physician about the desirability of discontinuing the drug.
This may require the addition of appropriate anticonvulsants or an increase in their dosages. The concomitant use of valproic acid and clonazepam may produce absence status. Laboratory Testing During Long-Term Therapy Periodic blood counts and liver function tests are advisable during long-term therapy with clonazepam. Risks of Abrupt Withdrawal The abrupt withdrawal of clonazepam, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus.
Therefore, when discontinuing clonazepam, gradual withdrawal is essential. While clonazepam is being gradually withdrawn, the simultaneous substitution of another anticonvulsant may be indicated. Caution in Renally Impaired Patients Metabolites of clonazepam are excreted by the kidneys; to avoid their excess accumulation, caution should be exercised in the administration of the drug to patients with impaired renal function.
Hypersalivation Clonazepam may produce an increase in salivation. This should be considered before giving the drug to patients who have difficulty handling secretions. Because of this and the possibility of respiratory depression, clonazepam should be used with caution in patients with chronic respiratory diseases. Diazepamt also is used to treat agitation, tremors , delirium, seizures, and hallucinations resulting from alcohol withdrawal. What are the uses for alprazolam vs.
Alprazolam Valium uses Alprazolam Xanax is used for the treatment of anxiety disorders and panic attacks Diazepam uses Diazepam is used for the treatment of disorders with anxiety. Diazepam also is used for the treatment of agitation, tremors, delirium, seizures, and hallucinations resulting from alcohol withdrawal.
It is used for the treatment of seizures, relief of muscle spasms in some neurological diseases, and for sedation during surgery. What are the side effects of alprazolam vs.
Effect of Other Drugs on the Pharmacokinetics of Clonazepam Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics. But as you said, I'll tapper it off gradually, not just stop it at once. Although clinical studies have not been performed, based on the involvement of the valium P 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam. The valium seems as if it had no effect at all, or if it does, very little. No need for a cross-over now, it's been 9 days. Anxiety disorders are characterized by: Seizures can occur in more severe cases of withdrawal. Diazepam also is used for the treatment of agitation, tremors, delirium, seizures, and hallucinations resulting from alcohol withdrawal. Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated. Diazepam Valium is an oral benzodiazepine medication used to treat anxiety. Both are available as generic drugs. Different side effects for alprazolam include 10mg and changes in weight. A crossover is normally done in stages, substituing a little at a time over several weeks. 1mg is most commonly used for alcohol withdrawal and diazepam for a range of drug withdrawal problems. Clonazepam meets three out clonazepam four of the criteria 1, clonazepam 1mg vs valium 10mg. There have been reports of neonatal flaccidity, respiratory and feeding difficulties and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy. Fluoxetine does not affect the pharmacokinetics of clonazepam.
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