Tooth discoloration brown, yellow, or gray staining has been reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.
Coadministration of probenecid is not recommended. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. The amoxicillin doses in rats and mice based on body surface area were approximately 4 and 2 times the maximum recommended adult human oral dose mg every 12 hours.
Augmentin is one of the workhorses of the pediatrician's office, prescribed for ear infections that are resistant to amoxicillin alone, sore throats and certain eye infections.
The drug is also a powerful agent against bronchitis and tonsillitis caused by bacteria though many cases of sore throat are viral in origin. In addition, the drug can fight pneumonia, urinary tract infections, gonorrhea, and skin infections.
Though Augmentin hasn't been conclusively shown to be safe during pregnancy, some studies suggest it is unlikely to do harm to pregnant women or their fetuses, according to a study in the British Journal of Clinical Pharmacology. Women who are pregnant should check with their doctors before taking the drug. The Food and Drug Administration classifies Augmentin as a class B drug, meaning there is no evidence for harm. Side effects The most common side effects for Augmentin are nausea, upset stomach, gas and diarrhea.
Largely, this is because clavulanic acid can irritate the gut, Geddes said. In addition, like other antibiotics, Augmentin wipes out a broad class of bacteria, so it may also kill "good" bacteria that line the gut and help digest foods. Augmentin can also leave people more prone to yeast infections — again, because it wipes out good bacterial populations that normally inhibit the growth of yeast.
Take the medicine carton or bottle to show the doctor. Do not take a double dose to make up for a forgotten dose. If you stop taking Augmentin Keep taking Augmentin until the treatment is finished, even if you feel better.
You need every dose to help fight the infection. If some bacteria survive they can cause the infection to come back. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them. The side effects below may happen with this medicine. Conditions you need to look out for Allergic reactions: Contact a doctor immediately if you get any of these symptoms. Studies in guinea pigs have shown that intravenous administration of ampicillin decreased the uterine tone, frequency of contractions, height of contractions, and duration of contractions; however, it is not known whether the use of AUGMENTIN in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.
In a single study in women with premature rupture of fetal membranes, it was reported that prophylactic treatment with AUGMENTIN may be associated with an increased risk of necrotizing enterocolitis in neonates. This analysis and other reported clinical experience have not identified differences in responses between the elderly and younger patients, but a greater sensitivity of some older individuals cannot be ruled out.
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache. The following adverse reactions have been reported for ampicillin-class antibiotics: Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.
These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, the drug should be discontinued, unless the opinion of the physician dictates otherwise.
Serious and occasional fatal hypersensitivity anaphylactic reactions can occur with oral penicillin. It has been reported more commonly in the elderly, in males, or in patients on prolonged treatment.
The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic-hepatocellular changes. The hepatic dysfunction, which may be severe, is usually reversible. Renal Interstitial nephritis and hematuria have been reported rarely.
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