Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. There was no evidence of teratogenicity or other adverse effects on embryo-fetal development when pregnant mice, rats or rabbits were treated orally with candesartan cilexetil alone or in combination with hydrochlorothiazide. Thiazides cross the placental barrier and appear in cord blood.
There is a risk of fetal or neonatal jaundice , thrombocytopenia , and possibly other adverse reactions that have occurred in adults. In such patients, ATACAND HCT therapy should be started under close medical supervision; they should be followed closely for the first 2 weeks of treatment and whenever the dose of candesartan or diuretic is increased. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system and by diuretics.
Patients whose renal function may depend in part on the activity of the renin-angiotensin system e. Potassium Abnormalities Drugs that inhibit the renin-angiotensin system can cause hyperkalemia. Hydrochlorothiazide can cause hypokalemia and hyponatremia.
Hypomagnesema can result in hypokalemia which appears difficult to treat despite potassium repletion. Monitor serum electrolytes periodically. In clinical trials of various doses of candesartan cilexetil and hydrochlorothiazide, the incidence of hypertensive Acute Myopia and Secondary Angle-Closure Glaucoma Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma.
Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible.
Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Hypersensitivity Reaction Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma , but are more likely in patients with such a history.
MRHD considered to be 32 mg for candesartan cilexetil and Hydrochlorothiazide may raise the serum uric acid level due to reduced clearance of uric acid and may cause or exacerbate hyperuricemia and precipitate gout in susceptible patients. Thiazides decrease urinary calcium excretion and may cause mild elevation of serum calcium. Systemic Lupus Erythematosus Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus. Carcinogenesis, Mutagenesis, Impairment Of Fertility No carcinogenicity studies have been conducted with the combination of candesartan cilexetil and hydrochlorothiazide.
AstraZeneca Product of Australia. Actavis Product of Canada. Deva Pharma Product of Turkey. Apotex Corporation Product of Australia. All prices are in USD. Average shipping time is 2 to 3 weeks. It is a combination of classes of drugs called angiotensin receptors agonists and thiazide diuretics, which reduce the secretion of hormones that causes blood vessels to narrow and increase pressure. By preventing the narrowing of blood vessels, the blood pressure is reduced.
This cause dizziness, weakness and confusion. It also causes increased thirst and frequent urination. An allergic reaction to the Atacand HCT drug can result in hives, swelling of the hands, face and difficulty breathing. A host of cardiovascular side effects that are less common include irregular heartbeats and heart blocks.
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